Dr. Valerie Johnson
Post-Doctoral Fellow at Colorado State University
Using Preactivated Mesenchymal Stem Cells to Treat Multi-Drug Resistant Infections in Dogs
Monday, September 9, 1:30 PM – 2:00 pM
Over the past several decades antimicrobial resistance has increased, in part due to overuse of antibiotics. These infections currently have limited therapeutic options, often resulting in extensive surgery, limb amputation, or death. New pharmaceutical agents are of limited value as the bacteria develop resistance to new therapeutics faster than new agents can be developed. Novel treatments are needed to enhance immune clearance of infection thus circumventing the ability of bacteria to develop resistance to antimicrobial drugs. Mesenchymal stem cells (MSC) have been demonstrated to have antimicrobial activity and studies in our lab have demonstrated clearance of biofilm infections not responsive to antibiotic treatment when pre-activated stem cells were combined with antibiotics. We hypothesized that pre-activated mesenchymal stem cells (aMSC) would be effective at clearing multi-drug resistant (MDR) infections in vitro and in vivo. Results of these studies suggest that aMSC do have anti-bacterial activity against MDR infections and can be effectively utilized to treat infections in which conventional therapies have failed.