Dr. Mohit Kapoor
Director of the Arthritis Research Program at the Krembil Research Institute, University Health Network
Novel Therapeutic Strategies to Counteract Cartilage Destruction during Osteoarthritis
Monday, September 9, 3:30 PM – 4:00 PM
Osteoarthritis (OA) is among the most prevalent chronic human health disorders and the most common form of arthritis. It is among the leading causes of disability in Canada and worldwide; and with increasing life expectancy, OA is a major socioeconomic and clinical concern. In OA, cartilage is destroyed and synovium gets inflamed, causing joint stiffness, pain and disability. The disease progresses relatively unnoticed; by the time it is diagnosed, the damage is often so severe that treatments are no longer effective. Specific mechanisms associated with the joint destruction during OA are largely unknown. Due to the lack of biomarkers, it is impossible to identify patients exhibiting early stages of OA, leading to severe joint destruction. Furthermore, due to poor understanding of the underlying disease mechanisms, no disease-modifying therapies to treat OA exist. Therefore, early detection and early intervention are critical to restore joint functions. This lecture will provide an overview of the recent advancements in the field of osteoarthritis and potential therapeutic targets for the treatment of osteoarthritis.