Dr. Boaz Arzi
Director, University of California Davis Veterinary Institute for Regenerative Cures
Perspectives on One-Health Regenerative Medicine
Sunday, September 8, 6:00 PM – 8:00 PM
Knowledge and experience derived from veterinary medicine represent an underused resource that could serve as a bridge between data obtained from diseases models in laboratory animals and human clinical trials. Naturally occurring disease in companion animals that display the defining attributes of similar, if not identical, diseases in humans hold promise for providing predictive proof of concept in the evaluation of new therapeutics and devices. This presentation will exemplify my perspective on comparative aspects of naturally occurring diseases in companion animals and discuss their current uses in translational medicine and potential benefits.
Update on Regenerative Approach for Mandibular Reconstruction
Monday, September 9, 1:00 PM – 1:30 PM
Utilizing a regenerative approach and specialized internal fixation for reconstruction of critical-size bone defects following segmental or rostral mandibulectomy, defect non-union fractures and other catastrophic mandibular fractures has been proven to be a viable and predictable method. Our experience over the past 8 years has demonstrated that in all cases immediate return to normal function and occlusion is present. Moreover, bone regeneration was observed clinically within 2 weeks and solid cortical bone formation within 3 months. Computed tomographic findings postoperatively and in follow-up examinations demonstrated newly regenerated mandibular bone with a bone density and porosity comparable to the contralateral side. Hence, regenerative approach to mandibular reconstruction using internal fixation and compression resistant matrix infused with rhBMP-2 provides an excellent solution for reconstruction of segmental mandibulectomy defects in dogs. This lecture will provide updates on our experience and knowledge gained from 8 years of regenerative approach to mandibular reconstruction.