Dr. Boaz Arzi

Director, University of California Davis Veterinary Institute for Regenerative Cures

Associate professor of dentistry and oral surgery at the department of Surgical and Radiological Sciences, UC Davis School of Veterinary Medicine. Dr. Arzi completed the residency-training program in dentistry and oral surgery and two years of fellowship in the UC Davis Department of Biomedical Engineering. He is a Diplomate of the American Veterinary Dental College (AVDC) and the European Veterinary Dental College (EVDC). Dr. Arzi is also a Founding Fellow of the AVDC in Oral and Maxillofacial Surgery. Dr. Arzi’s clinical and research focus is on oral maxillofacial disorders and regenerative solutions in dogs and cats. His lab also investigates TMJ disorders and treatments across species. He is a co-principal investigator on the use of adipose-derived mesenchymal stem cells (MSC) for feline gingivostomatitis and also a co-principal investigator on the use of rhBMP-2 for mandibular reconstruction. Furthermore, Dr. Arzi works in collaboration with the biomedical engineering group at UC Davis for the development of biological solutions to TMJ disorders in humans. Dr. Arzi is the director of the school’s Veterinary Institute for Regenerative Cures (VIRC). Ultimately, Dr. Arzi’s work is translational with the aim of One Health treatment modalities for both human and animal health.
 

Perspectives on One-Health Regenerative Medicine

Sunday, September 8, 6:00 PM – 8:00 PM

 

Knowledge and experience derived from veterinary medicine represent an underused resource that could serve as a bridge between data obtained from diseases models in laboratory animals and human clinical trials. Naturally occurring disease in companion animals that display the defining attributes of similar, if not identical, diseases in humans hold promise for providing predictive proof of concept in the evaluation of new therapeutics and devices. This presentation will exemplify my perspective on comparative aspects of naturally occurring diseases in companion animals and discuss their current uses in translational medicine and potential benefits.

 

 

Update on Regenerative Approach for Mandibular Reconstruction

Monday, September 9, 1:00 PM – 1:30 PM

 
Utilizing a regenerative approach and specialized internal fixation for reconstruction of critical-size bone defects following segmental or rostral mandibulectomy, defect non-union fractures and other catastrophic mandibular fractures has been proven to be a viable and predictable method. Our experience over the past 8 years has demonstrated that in all cases immediate return to normal function and occlusion is present. Moreover, bone regeneration was observed clinically within 2 weeks and solid cortical bone formation within 3 months. Computed tomographic findings postoperatively and in follow-up examinations demonstrated newly regenerated mandibular bone with a bone density and porosity comparable to the contralateral side. Hence, regenerative approach to mandibular reconstruction using internal fixation and compression resistant matrix infused with rhBMP-2 provides an excellent solution for reconstruction of segmental mandibulectomy defects in dogs. This lecture will provide updates on our experience and knowledge gained from 8 years of regenerative approach to mandibular reconstruction.