Conference Program

NAVRMA 2018 Program

“New Frontiers in Regenerative Medicine”
Sacramento California – Sawyer Hotel

 

Thursday, September 6: Afternoon

2:00 PM – 5:00 PM

Strategic Planning for NAVRMA – Open to all interested attendees

Help decide the future of NAVRMA. Includes a discussion of partnership opportunities, with a brief presentation by Dr. Jan Nolta (UC Davis), representing the International Society of Cell and Gene Therapy (ISCT).

6:00 PM – 8:00 PMOpening Keynote Lecture and Reception: Dr. Hiro Nakauchi, Professor of Genetics, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University: “Exploiting the organ niche for interspecies organogenesis.”
Introduction and opening remarks by Kurt Hankenson.

 

Friday, September 7: Morning

7:30 AM – 8:30 AMBreakfast with sponsors
8:30 AM – 9:30 AMPlenary Session 1: Michael Longaker, MD, Co-Director, Stanford Institute for Stem Cell Biology and Regenerative Medicine:
“Skeletal Stem Cells”
9:30 AM – 1:30 PM

Behind-the-scenes tour at University of California Davis

This comprehensive tour will visit teaching and clinical facilities, including recent innovations such as cone beam CT, PET/CT and linear accelerator, research facilities focused on musculoskeletal research as well as stem cell laboratories, and 3D printing facilities in Biomedical Engineering. Limited to 25 attendees. Sign up for the tour >

9:30 AM – 10:00 AMCoffee break with sponsors
10:00 AM – 12:00 PMNew Frontiers in Regenerative Medicine (at the Cutting Edge)
4 X 30 minute presentations from faculty attendees, moderated by Mark Hurtig, Guelph University and Kyla Ortved, University of Pennsylvania

Gerlinde R. Van de Walle, DVM, PhD, Cornell University, Baker Institute: “Towards a better understanding of MSC heterogeneity using single cell RNA-sequencing”

Mike Mienaltowski, DVM, PhD, University of California at Davis: “Considering tissue niche and residential progenitors in tendon repair”


Susan Volk
, VMD, PhD, University of Pennsylvania: “Biologically-based tissue engineering”

Chris Murphy, DVM, PhD, University of California at Davis: “Engineering and the Cornea”

 

Friday, September 7: Afternoon

12:00 PM – 1:30 PMLunch with sponsors and posters
1:30 PM – 3:00 PMOral Session 1: Stem Cell Basics
Moderators: Lauren Schnabel and Rebecca Harman
Breakout Session 1: Best Practices in Stem Cell Therapeutics – Introduction/Perspectives
Organizers: Dori Borjesson and Tracy Webb
1:30 – 1:45 Ian Tobias, Western University (Ontario) “Canine Embryo-Derived and Induced Pluripotent Stem Cells: Contributions, Challenges and Perspectives”

1:45 – 2:00 Maria Questa, UC Davis: “Generation of transgenic OCT4-eGFP canine induced pluripotent stem cell lines for pluripotency assessment”

2:00 – 2:15 Nathan Frank, Terumo BCT: “Expansion of Canine Adipose-Derived Mesenchymal Stem Cells in an Automated, Hollow-Fiber Bioreactor System using Pooled Canine Cryoprecipitate as a Membrane Coating Reagent”

2:15 – 2:30 Aileen Rowland, Texas A&M: “Bone marrow supernatant is a suitable replacement for fetal bovine serum in the isolation of equine bone marrow derived mesenchymal stem cells”

2:30 – 2:45 Hamed Alizadeh, Guelph University: “Cell Identity, proliferation, and cytogenitc assessment of equine umbilical cord blood mesenchymal stromal cells”

2:45 – 3:00 Mathieu Spriet, UC Davis: “Preliminary Experience with Positron Emission Tomography Stem Cell Tracking in the Horse”

1:30 – 1:45 Introduction

1:45 – 2:15 Dr. Jan Nolta, UC Davis: “Summary of ISCT experiences in developing best practices and white papers on human side”

2:15 – 2:45 Dr. Lynne Boxer: “Summary of adverse events reported thus far and need for development of best practices”

2:45 – 3:00 Summary and next sessions

3:00 PM – 3:30 PMAfternoon break with sponsors
3:30 PM – 5:00 PMOral Session 2: Immunomodulation
Moderators: Laurie Goodrich and Jeff Mason
Breakout Session 2: Best Practices in Developing Stem Cell Therapeutics: Cell Culture and Release Criteria
Organizers: Dori Borjesson and Tracy Webb
3:30 – 3:45 Lauren Schnabel, NC State: “Platelet-rich plasma lysate therapy increases synoviocyte proliferation and hyaluronic acid production while protecting chondrocytes from synoviocyte-derived inflammatory mediators”

3:45 – 4:00 Kyla Ortved, University of Pennsylvania: “Autologous protein solution mitigates the inflammatory cascade in stimulated equine chondrocytes”

4:00 – 4:15 Nopamanee Taechangam, UC Davis: “Mechanisms Utilized by Feline Mesenchymal Stem Cells to Inhibit T-Lymphocyte Proliferation”

4:15 – 4:30 Sarah Lepage, Guelph: “Equine cord blood MSCs have greater differentiation and similar immunosuppressive potential to donor-matched cord tissue MSCs”

4:30 – 4:45 Alix Berglund, NC State: “Untreated and TGF-beta2-treated equine bone marrow-derived mesenchymal stem cells have similar immunomodulatory properties in vitro”

4:45 – 5:00 Catherine Takawira, Louisiana State University: “Autologous Adipose-Derived Multipotent Stromal Cells on Xenografts Reduce the Systemic Response”

Panel Discussion for White Paper
5:00 PM – 6:30 PMPoster Judging Session

 

Saturday, September 8: Morning

7:30 AM – 8:30 AMBreakfast with sponsors
8:30 AM – 9:30 AMPlenary Session 2: Dr. Brian Johnstone, Oregon Health Sciences University: “Stem Cells for Cartilage Repair: The Good, The Bad, and The Ugly”
9:30 AM – 10:00 AMCoffee break with sponsors
10:00 AM – 12:00 AMNew Frontiers in Regenerative Medicine (in Translation)
4 X 30 minute presentations from faculty attendees, moderated by Madhu Dhar, University of Tennessee and Gerlinde Van De Wale, Cornell University

Jen Barrett, PhD, DVM Virginia Tech: “Cell Therapy for the Treatment of Osteoarthritis”

Kristen Thane, DVM, Regenerative Medicine Laboratory, Tufts University: “Immunomodulatory effects of canine umbilical cord tissue mesenchymal stem cells and extracellular vesicles”

John Peroni, DVM, PhD University of Georgia: “Platelet Lysate obtained via plateletpheresis and the regulation of innate immune responses in horses”

Lauren Schnabel, DVM, PhD, North Carolina State University: “A new approach to infectious arthritis: understanding bacterial behavior in synovial fluid and developing a novel therapeutic that is both antimicrobial and chondroprotective.”

 

Saturday, September 8: Afternoon

12:00 PM – 1:30 PMLunch with sponsors and posters
1:30 PM – 3:00 PMOral Session 3: Stem Cell Therapy for Soft Tissue Disease
Moderators: Ashlee Watts and Kate Birdwhistell
Breakout Session 3: Best Practices in Developing Stem Cell Therapeutics: Donor Qualifications
Organizers: Dori Borjesson and Tracy Webb
1:30 – 1:45 Laurel Saldinger, UC Davis: “Adipose-derived mesenchymal stem cells as a potential therapy for equine recurrent uveitis”

1:45 – 2:00 Cara Clouse, Wake Forest Institute for Regenerative Medicine: “Stem Cells for Neurovascular Erectile Dysfunction”

2:00 – 2:15 Suzanne Mund, University of Saskaatchewan: “Homing and engraftment of intravenously administered equine cord blood derived multipotent mesenchymal stromal cells (CB-MSCs) to surgically created wounds in horses: an observational pilot project”

2:15 – 2:30 Rebecca Harman, Cornell University: “Equine mesenchymal stromal cell-derived PAI-1 and tenascin-C promote wound healing”

2:30 – 2:45 Mandi Lopez, Louisiana State University: “Insulin Secretion by Pancreatic Cell Clusters from Feline Adipose Derived Multipotent Stromal Cells Responds to Glucose Concentration”

2:45 – 3:00 Francis Karanu, Likarda LLC: “Progress Towards Islet and Stem Cell Therapies for the Management of Diabetes In Pets”

1:30 – 2:15 Helen Newman, Veterinary Transplant Services: “Donor selection for human and veterinary transplantation and discussing tissue donation with owners”

2:15 – 3:00 Panel discussion for white paper

3:00 PM – 3:30 PMAfternoon break with sponsors
3:30 PM – 5:00 PMOral Session 4: Musculoskeletal Regeneration
Moderators: Scott Hopper and Hamed Alizadeh
Breakout Session 4: Practitioner Primer on FDA Product Development
Organizer: Robert Harman
3:30 – 3:45 Jeff Mason, Utah State: “In Vivo Gene Therapy of the Equine Distal Extremity with a Therapeutic Viral Vector Using a Standing Regional Limb Procedure”

3:45 – 4:00 Aimee Colbath, Colorado State University: “Extracorporeal shockwave promotes osteogenesis of equine bone marrow-derived mesenchymal stem cells”

4:00 – 4:15 Stephane Maddens, Vetbiobank: “Newborn tissues for cartilage regeneration: A comparative analysis of the chondrogenic potential of umbilical cord matrix and umbilical cord-derived mesenchymal stem/stromal cells (MSC)”

4:15 – 4:30 Kristina Kiefer, University of Minnesota: “Allogeneic Stem Cell Therapy and Joint Irrigation as an Intra-articular Adjuvant Therapy for Canine Osteoarthritis: A Safety and Efficacy Assessment”

4:30 – 4:45 Takashi Taguchi, Louisiana State University: “Agmatine for Pain Management in Dogs with Coxofemoral Joint Osteoarthritis”

4:45 – 5:00 Kate Birdwhistell, University of Georgia: “Porcine Platelet Lysate: A Culture Supplement for Porcine Osteochondral Graft Storage?”

Dos and Don’ts and How You Can Be Involved
5:30 PM – 6:30 PMClosing Keynote Lecture: Farshid Guilak, PhD, Departments of Orthopaedic Surgery, Developmental Biology, and Biomedical Engineering, Washington University, St. Louis: “Engineering Designer Stem Cells Using CRISPR-Cas9 Genome Editing: Developing the Next Generation of Cell-based Therapies”
6:30 PM – 8:00 PMClosing remarks by Michael Lairmore, Dean, UC Davis School of Veterinary Medicine

Closing Reception and Awards

 

Sunday, September 9: Morning

7:30 AM – 8:30 AMBreakfast with sponsors
8:30 AM – 10:30 AMNew Frontiers in Regenerative Medicine (in Clinical Practice)
4 X 30 minute presentations from faculty attendees

Ashlee Watts, DVM, PhD, Assistant Professor, Texas A&M University:
“A randomized, controlled trial of the effects of resveratrol administration in performance horses with lameness localized to the distal tarsal joints”

Tracy Webb, Colorado State University: “MSC and IBD in the CAT”

Kristina Kiefer, University of Minnesota: “Double-blinded, Placebo Controlled Study Evaluating the Safety and Efficacy of Intravenous Allogeneic Adipose Stromal Cell Therapy for Canine Osteoarthritis”

Bob Harman, VetStem: “Results of GLP Canine Stem Cell Safety Study of Intraarticular Stem Cells”

10:30 AM – 11:00 AMCoffee break with sponsors
11:00 AM – 12:00 PMReports from breakout sessions
12:00 PMMeeting adjournment